24744-66-9

Upstream product

• 24744-65-8 (diphenylphosphino)acetaldehyde diethyl acetal 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 64-17-5 ethanol 
• 1106973-89-0 C₃₅H₃₇O₇P 
• 603-35-0 triphenylphosphine 

Downstream Products

• 101374-02-1 (1,3-dithiolan-2-yl-diphenylmethyl)phosphane oxide 
• 101374-03-2 S-<2-(2-diphenylphosphanoxido)-vinylthio>-ethyl thioacetate 
• 269400-30-8 6-butyl-5-diphenylphosphoryl-2,2-dimethyl-2,3,5,6-tetrahydropyran-4-one 
• 269400-24-0 (E)-5-diphenylphosphoryl-6-ethoxy-2-methyl-5-hexen-3-yn-2-ol 
• 269400-25-1 (E)-5-diphenylphosphoryl-6-ethoxy-5-hexen-3-yn-2-ol 
• 269400-26-2 (E)-4-diphenylphosphoryl-5-ethoxy-4-penten-2-yn-1-ol 
• 269400-27-3 5-diphenylphosphoryl-2,2-dimethyl-2,3-dihydro-4H-pyran-4-one 
• 269400-23-9 (Z)-(2-ethoxy-1-iodovinyl)diphenylphosphine oxide 
• 141031-07-4 (E)-(2-ethoxyvinyl)diphenylphosphine oxide 

Relevant academic research and scientific papers

Diphenylphosphinoylethylidene (DPE) acetals: an alternative protective strategy in glycochemistry

Diphenylphoshinoylethyne reacts with diols under basic conditions to produce cycloacetalic phosphine oxides. The reaction appears to be general and particularly effective with carbohydrate derivatives. The 2-(diphenylphoshinoyl)ethylidene (DPE) acetals produced are stable in acidic media while they can be cleaved under reductive and/or basic conditions: base-catalyzed transacetalization is a method of choice for their mild and effective deprotection.

Synthesis of 5-diphenylphosphinoyl-2,3-dihydropyran-4-ones

5-Diphenylphosphinoyl-2,3-dihydropyran-4-ones are readily prepared from the corresponding 5-diphenylphosphinoyl-1-buten-3-yne under mild acidic conditions. The phosphorus substituted pyrones are converted to more substituted pyrones via 1,4-addition of co