247564-66-5

Usage

Uses

Used in Pharmaceutical Industry:
4,6-Difluoroindole-2-carboxylic acid is used as a building block for the synthesis of new compounds with potential therapeutic applications. Its unique structure and properties make it a valuable component in the development of drugs for the treatment of various diseases and medical conditions.
Used in Agrochemical Industry:
4,6-Difluoroindole-2-carboxylic acid is used as a starting material for the synthesis of agrochemicals, such as pesticides and herbicides. Its unique properties can contribute to the development of more effective and environmentally friendly products.
Used in Materials Science:
4,6-Difluoroindole-2-carboxylic acid is used as a component in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity. Its incorporation into materials can lead to advancements in various fields, including electronics, coatings, and adhesives.

InChI:InChI=1/C9H5F2NO2/c10-4-1-6(11)5-3-8(9(13)14)12-7(5)2-4/h1-3,12H,(H,13,14)

Upstream product

• 1550-35-2 2,4-difluorobenzaldehyde 
• 247565-75-9 ethyl 2-(2-(2,4-difluorophenyl)hydrazono)propanoate 
• 394222-99-2 methyl-4,6-difluoroindole-carboxylate 
• 870536-93-9 ethyl 4,6-difluoro-1H-indole-2-carboxylate 

Downstream Products

• 199526-97-1 4,6-difluoro-1H-indole 
• 882043-82-5 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-3'-O-mesyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole 
• 943524-16-1 1-(2'-deoxy-5'-O-tert-butyldiphenylsilyl-β-D-erythro-pentofuranosyl)-4,6-difluoroindole 
• 882043-76-7 1-[2'-deoxy-3',5'-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-4,6-difluoroindole 

Relevant academic research and scientific papers

Synthesis of Azepino[1,2-a]indole-10-amines via [6+1] Annulation of Ynenitriles with Reformatsky Reagent

Lewis acid-catalyzed [6+1] annulation reactions of 2-cyano-1-propargyl- and 2-alkynyl-1-cyanomethyl-indoles with Reformatsky reagent are described. 8-Aryl, 8-alkyl-, 8-hetaryl-, 9-aryl, and 9-alkyl-azepino[1,2-a]indole amines were obtained through a 7-endo-mode cyclization of the β-aminoacrylate intermediates. The antiproliferative activity of the azepino[1,2-a]indoles analogs against the HCT-116 cells were also examined.

Indole derivatives

Novel indole derivatives of formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 is fluorine, or chlorine, and R2 is hydrogen, or fluorine, which are SGLT inhibitors and are useful for treatment or prevention of diabetes and related conditions.

Synthesis and structure of fluoroindole nucleosides

Chemically modified bases are frequently used to stabilize nucleic acids, to study the driving forces for nucleic acid structure formation, and to tune DNA and RNA hybridization conditions. Nucleoside analogues are chemical means to investigate hydrogen bonds, base stacking, and solvation as the three predominant forces that are responsible for the stability of nucleic acids. To obtain deeper insight into the contributions of these interactions to RNA stability, we decided to synthesize some novel nucleic acid analogues where the nucleobases are replaced by fluoroindoles. Fluorinated indoles can be compared with fluorinated benzimidazoles to determine the role of nitrogen in five-membered ring systems. The synthesis of fluoroindole ribonucleosides as well as the X-ray crystal structures of all synthesized fluoroindole ribonucleosides are reported here. These compounds could also be building blocks for a variety of biologically active RNA analogues.

Synthesis of fluorinated indoles as RNA analogues

Nucleoside analogues are chemical means to investigate hydrogen bonds, base stacking, and solvation as the three predominant forces that are responsible for the stability of secondary structure of nucleic acids. To obtain deeper insight into the contributions of these interactions to RNA stability apart from the ones exerted by the predominant nucleosides we decided to synthesize some novel nucleic acid analogues where the nucleobases are replaced by fluoroindoles. Fluorinated indoles can be compared to fluorinated benzimidazoles to determine the role of nitrogen in five membered ring system. The synthesis of fluoroindole ribonucleosides is described here. Copyright Taylor & Francis Group, LLC.