247583-71-7

Basic information

• Product Name: 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic Acid
• Synonyms: 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic Acid;1H-Pyrazole-3-carboxylic acid, 1-methyl-4-nitro-5-propyl-
• CAS NO: 247583-71-7
• Molecular Formula: C₈H₁₁N₃O₄
• Molecular Weight: 213.19064
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 247583-71-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 392.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Dimethyl Sulfoxide, Mehtnaol
• PKA: 1.49±0.41(Predicted)
• CAS DataBase Reference: 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic Acid(247583-71-7)
• EPA Substance Registry System: 1-Methyl-4-nitro-5-propyl-1H-pyrazole-3-carboxylic Acid(247583-71-7)

Safety Data

• Hazardous Substances Data: 247583-71-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Solid

Upstream product

• 36983-31-0 ethyl 3-butyrylpyruvate 
• 247583-70-6 1-methyl-5-propyl-1H-pyrazole-3-carboxylic acid 
• 60-34-4 methylhydrazine 

Downstream Products

• 247583-72-8 1-methyl-4-nitro-5-propyl-3-pyrazolecarboxamide 
• 247583-78-4 4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide 
• 501120-40-7 5-(2-ethoxyphenyl)-2-methyl-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one 
• 501120-42-9 5-(5-chlorosulfonyl-2-ethoxyphenyl)-2-methyl-3-propyl-6,7-dihydro-2H-pyrazolo[4,3-d]pyrimidin-7-one 
• 501120-38-3 4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide 

Relevant articles and documents

Synthesis and properties of isoviagra [1]. A 2-methyl-2H-pyrazolo[4,3-d]pyrimidin-7-one isomer of Viagra

The synthesis and spectral properties (ir, ms, nmr) of a substituted 2-methyl-2H-pyrazolo[4,3-d]-pyrimidin-7-one (3), an isomer of Viagra, are described. The key synthon, 4-amino-1-methyl-5-propyl-3-pyrazolecarboxamide (7), is prepared via the reaction of ethyl 2,4-dioxoheptanoate with methylhydrazine, followed by cyclization, nitration, amidation, and nitro group reduction. Interaction of 7 with 2-ethoxybenzoyl chloride yielded the respective bis-amide (8) which was cyclized in polyphosphoric acid to the corresponding pyrazolo[4,3-d]pyrimidin-7-one derivative 9. Chlorosulfonylation of 9, and subsequent treatment with 1-methylpiperazine furnished isoViagra (3).