24760-60-9

Upstream product

• 10061-52-6 1-(3,5-dimethoxy-4-hydroxyphenyl)-1-propanol 
• 134-96-3 syringic aldehyde 
• 6766-82-1 4-n-propylsyringol 

Downstream Products

• 127311-32-4 (1R*,2S*,3R*)-5,7-dimethoxy-3-ethyl-6-hydroxy-1-(4-methoxyphenyl)-2-methyl-2,3-dihydroindene 
• 127311-32-4 (1S*,2S*,3R*)-5,7-dimethoxy-3-ethyl-6-hydroxy-1-(4-methoxyphenyl)-2-methyl-2,3-dihydroindene 
• 127311-24-4 (1S*,2S*,3R*)-5,7-dimthoxy-3-ethyl-6-hydroxy-2-methyl-1-phenyl-2,3-dihydroindene 
• 127311-24-4 (1R*,2S*,3R*)-5,7-dimthoxy-3-ethyl-6-hydroxy-2-methyl-1-phenyl-2,3-dihydroindene 

Relevant academic research and scientific papers

Formal Cycloaddition of Benzylic Cations with Alkenes

The reaction of benzylic cations with styrenes affords dihydro(1H)indenes in good yield via a formal atom cycloadditon.The cations were generated from quinone methides and benzylic alcohols. (E)-Styrenes participate in the reaction with remarkable stereoselectivity affording dihydro(1H)indenes with three stereogenic centers with >40:1 diastereoselectivity.A possible transition state for the reaction is discussed.Less activated alkenes such as dihydropyran and methylcyclohexane afforded cycloadducts in 66percent and 51percent yields, respectively.

Synthesis of Dihydro-1H-indenes via a Formal 3 + 2 Cycloaddition of p-Quinone Methides and Styrenes

The synthesis of dihydro-1H-indenes via the formal 3 + 2 cycloaddition of an electron-rich alkene and a p-quinone methide is reported.