2477-61-4

Usage

Uses

Used in Medical Diagnostics:
17-Hydroxypregna-1,4-diene-3,20-dione is used as a diagnostic tool for assessing adrenal function, aiding in the detection and monitoring of endocrine disorders such as congenital adrenal hyperplasia. Its measurement in blood tests provides valuable insights into the patient's hormonal balance and helps in tailoring appropriate treatment plans.
Used in Endocrine Disorder Treatment:
In the treatment of certain endocrine disorders, 17-hydroxyprogesterone is used as a therapeutic agent to help regulate hormonal imbalances. Its administration can assist in managing symptoms and correcting the underlying hormonal deficiencies associated with these conditions.
Used in Reproductive Health:
17-Hydroxypregna-1,4-diene-3,20-dione is used as a treatment for infertility and menstrual disorders, where it may help to regulate hormonal levels and improve reproductive outcomes. Its influence on the hormonal balance is crucial for supporting normal reproductive function.
Used in Oncology:
In the field of oncology, 17-hydroxyprogesterone is being investigated for its potential therapeutic applications in the treatment of certain types of cancer. Its role in modulating hormonal pathways makes it a candidate for research into cancer therapies, particularly those related to hormone-sensitive tumors.
Used in Pharmaceutical Research:
17-Hydroxypregna-1,4-diene-3,20-dione is also used in pharmaceutical research as a key compound in the development of new drugs targeting various diseases. Its multifaceted role in the body makes it a valuable subject for exploring its potential in treating a range of conditions.

Upstream product

• 897-06-3 Androsta-1,4-diene-3,17-dione 
• 7162-55-2 17α-ethynyl-17β-hydroxy-1,4-androstadien-3-one 
• 7487-94-7 mercury (II) chloride 
• 83509-37-9 17β-ethynyl-17α-hydroxyandrosta-1,4-dien-3-one 
• 74-88-4 methyl iodide 
• 74-83-9 methyl bromide 
• 74-87-3 methylene chloride 
• 570-59-2 4,5α-dihydro-17α-hydroxyprogesterone 
• 92688-03-4 17α-Hydroxy-3-oxoandrosta-1,4-diene-17β-carbonitrile 
• 77881-13-1 17β-cyano-17α-hydroxy-4-androsten-3-one 
• 68-96-2 17-hydroxyprogesterone 

Downstream Products

• 1249-67-8 17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate 

Relevant academic research and scientific papers

Preparation method of 1,6-didehydrogenation-17a-hydroxyl progesterone product

The invention provides a preparation method of a 1,6-didehydrogenation-17a-hydroxyl progesterone product. The preparation method includes the steps that 1,4-androstenedione (IDD) is adopted as a raw material, firstly, IDD molecules and acetone cyanohydrin

Method for preparing 1,6-didehydro-17a-hydroxyprogesterone product

The invention provides a method for preparing a 1,6-didehydro-17a-hydroxyprogesterone product. The method comprises the steps that firstly soybean oil is adopted to process a by-product to obtain phytosterol, then the phytosterol is fermented to obtain ID

Microbial hydroxylation of hydroxyprogesterones and α-glucosidase inhibition activity of their metabolites

Microbial transformation of 11α-hydroxyprogesterone (1) with Cunninghamella elegans, Gibberella fujikuroi, Fusarium lini, and Candida albicans yielded 11α,15α,16α-trihydroxypregn-4-ene-3,20-dione (3), 11α-hydroxy-5α-pregnane-3,20-dione (4), 6β,11α- dihydroxypregn-4-ene-3,20-dione(5), 11α-hydroxypregna-1,4-diene-3,20-dione (6), 11α,17β-dihydroxyandrost-4-en-3-one (7), and 11α,15α-dihydroxypregn-4-ene-3,20-dione (8). On the other hand, microbial transformation of 17α-hydroxyprogesterone (2) with Cunninghamella elegans and Fusarium Uni yielded 11α,17α- dihydroxypregn-4-ene-3,20-dione (9), and 17α-hydroxypregna-1,4-diene-3,20- dione (10). The structures of the metabolites 3-10 were deduced on the basis of spectroscopic methods. Compound 3 was identified as a new metabolite, which exhibited a promising inhibitory activity against the α-glucosidase enzyme.

17β-ethynylsteroids and process for preparing same

This is disclosed novel intermediates, i.e. 17β-ethynylsteroids, which are useful for the preparation of corticoids such as hydrocortisone and prednisolone, and a process for preparing the same.