2477-61-4

Basic information

• Product Name: 17-hydroxypregna-1,4-diene-3,20-dione
• CAS NO: 2477-61-4
• Molecular Formula: C₂₁H₂₈O₃
• Molecular Weight: 328.4452
• Mol File: 2477-61-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 485.6°C at 760 mmHg
• Flash Point: 261.6°C
• Density: 1.17g/cm³
• Vapor Pressure: 1.82E-11mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: 17-hydroxypregna-1,4-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 17-hydroxypregna-1,4-diene-3,20-dione(2477-61-4)
• EPA Substance Registry System: 17-hydroxypregna-1,4-diene-3,20-dione(2477-61-4)

Safety Data

• Hazardous Substances Data: 2477-61-4(Hazardous Substances Data)

Usage

General Description

17-hydroxypregna-1,4-diene-3,20-dione, also known as 17-hydroxyprogesterone, is a natural steroid hormone produced by the adrenal glands and the gonads. It is a precursor to the synthesis of other important hormones, such as cortisol and androstenedione, and plays a vital role in the regulation of various physiological processes, including metabolism, immune function, and reproductive health. Additionally, 17-hydroxyprogesterone is also used as a medical diagnostic tool for assessing adrenal function and for monitoring the treatment of certain endocrine disorders, such as congenital adrenal hyperplasia. Furthermore, it has been investigated for its potential therapeutic applications in the treatment of conditions such as infertility, menstrual disorders, and certain types of cancer.

Upstream product

• 74-88-4 methyl iodide 
• 74-83-9 methyl bromide 
• 74-87-3 methylene chloride 
• 7487-94-7 mercury (II) chloride 
• 83509-37-9 17β-ethynyl-17α-hydroxyandrosta-1,4-dien-3-one 
• 570-59-2 4,5α-dihydro-17α-hydroxyprogesterone 
• 92688-03-4 17α-Hydroxy-3-oxoandrosta-1,4-diene-17β-carbonitrile 
• 7162-55-2 17α-ethynyl-17β-hydroxy-1,4-androstadien-3-one 
• 897-06-3 Androsta-1,4-diene-3,17-dione 
• 68-96-2 17-hydroxyprogesterone 
• 77881-13-1 17β-cyano-17α-hydroxy-4-androsten-3-one 

Downstream Products

• 1249-67-8 17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate 

Relevant articles and documents

SYNTHESIS OF CORTEXOLONE PHOSPHATE

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Preparation method of 1,6-didehydrogenation-17a-hydroxyl progesterone product

The invention provides a preparation method of a 1,6-didehydrogenation-17a-hydroxyl progesterone product. The preparation method includes the steps that 1,4-androstenedione (IDD) is adopted as a raw material, firstly, IDD molecules and acetone cyanohydrin

Microbial hydroxylation of hydroxyprogesterones and α-glucosidase inhibition activity of their metabolites

Microbial transformation of 11α-hydroxyprogesterone (1) with Cunninghamella elegans, Gibberella fujikuroi, Fusarium lini, and Candida albicans yielded 11α,15α,16α-trihydroxypregn-4-ene-3,20-dione (3), 11α-hydroxy-5α-pregnane-3,20-dione (4), 6β,11α- dihydroxypregn-4-ene-3,20-dione(5), 11α-hydroxypregna-1,4-diene-3,20-dione (6), 11α,17β-dihydroxyandrost-4-en-3-one (7), and 11α,15α-dihydroxypregn-4-ene-3,20-dione (8). On the other hand, microbial transformation of 17α-hydroxyprogesterone (2) with Cunninghamella elegans and Fusarium Uni yielded 11α,17α- dihydroxypregn-4-ene-3,20-dione (9), and 17α-hydroxypregna-1,4-diene-3,20- dione (10). The structures of the metabolites 3-10 were deduced on the basis of spectroscopic methods. Compound 3 was identified as a new metabolite, which exhibited a promising inhibitory activity against the α-glucosidase enzyme.