24773-79-3Relevant academic research and scientific papers
Simple synthesized Mannich bases as ligands in Cu-catalyzed N-arylation of imidazoles in water
Zhu, Yefeng,Shi, Yixing,Wei, Yunyang
, p. 1009 - 1013 (2010)
1,4-Bis(2-hydroxy-5-methoxybenzyl)piperazine and its analogues were used as efficient ligands for CuI-catalyzed N-arylation of imidazoles with aryl halides in water under mild conditions (120 °C for 12 h) with 10 mol% of CuI, 20 mol% of the Mannich base, and two equivalents of KOH or K2CO 3 in the presence of 10 mol% phase transfer catalyst (n-Bu) 4NBr. A variety of products were synthesized in moderate to excellent yields using this inexpensive catalytic system. Springer-Verlag 2010.
