24782-72-7

Upstream product

• 63329-53-3 lobenzarit 

Downstream Products

• 86611-60-1 6-Chloro-9-(4-methanesulfonylamino-2-methoxy-phenylamino)-acridine-4-carboxylic acid carbamoylmethyl-amide 
• 86611-59-8 6-Chloro-9-(4-methanesulfonylamino-2-methoxy-phenylamino)-acridine-4-carboxylic acid methylamide 
• 86611-57-6 6-Chloro-9-(4-methanesulfonylamino-2-methoxy-phenylamino)-acridine-4-carboxylic acid amide 
• 86611-55-4 6-Chloro-9-(4-methanesulfonylamino-2-methoxy-phenylamino)-acridine-4-carboxylic acid 4-nitro-phenyl ester; hydrochloride 
• 106626-77-1 6-Chloro-acridine-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 86632-08-8 p-nitrophenyl 3-chloro-9-oxoacridan-5-carboxylate 

Relevant academic research and scientific papers

Potential antitumor agents. 38. 3-Substituted 5-carboxamido derivatives of amsacrine

The synthesis and biological evaluation of a series of 3-substituted 5-carboxamido derivatives of amsacrine (m-AMSA) are described. This series was developed as the result of previous quantitative structure-activity relationship (QSAR) studies of the antitumor activity of 9-anilinoacridine derivatives. In agreement with these studies, this class of compounds, possessing a variety of small nonpolar groups at the 3-position, together with very hydrophilic carboxamido groups at the 5-position, have high in vivo activity against animal leukemia models.

Synthesis of Substituted 9-Oxo-9,10-dihydroacridine-4-carboxylic Acids. I. Factors Affecting the Direction of Ring Closure of Substituted N-(2-Carboxyphenylamino)benzoic Acids

The cyclodehydration of 16 substituted N-(2-carboxyphenylamino)benzoic acids to substituted 9-oxo-9,10-dihydroacridine-4-carboxylic acids with conc.H2SO4, POCl3 and ethyl polyphosphate (epp) has been studied by h.p.l.c.Direction of ring closure can be qua