24787-83-5

Usage

InChI:InChI=1/C17H24N2O5/c1-4-11(2)14(15(20)18-12(3)16(21)22)19-17(23)24-10-13-8-6-5-7-9-13/h5-9,11-12,14H,4,10H2,1-3H3,(H,18,20)(H,19,23)(H,21,22)

Upstream product

• 212070-51-4 Cbz-L-Ile-L-Ala-OEt 
• 3160-59-6 N-Cbz-L-Isoleucine 

Downstream Products

• 212070-52-5 ((1S,2S)-2-Methyl-1-{(S)-1-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-ethylcarbamoyl}-butyl)-carbamic acid benzyl ester 
• 212070-53-6 (2S,3S)-2-{2-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-propionylamino]-2-methyl-propionylamino}-3-methyl-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of the endothiopeptide BOC-Trp-Ile-Ala-Aib-Ile- ValΨ[CSNH]Aib-Leu-Aib-Pro-OMe by a variation of the 'azirine/oxazolone method'

The synthesis of the decaendothiopeptide BOC-Trp-Ile-Ala-Aib-Ile- ValΨ[CSNH]Aib-Leu-Aib-Pro-OMe is described. The introduction of the thioamide group next to the bulky Aib occurred via a variation of the 'azirine/oxazolone method' without epimerisation. The structure of the decaendothiopeptide was established by single-crystal X-ray crystallography, thereby two types of helices could be observed.

Process for preparing antibody

A process for preparing a gut glucagon antigen composed of a peptide-carrier complex is disclosed, which comprises using as hapten a peptide represented by the following general formula; wherein R represents a hydrogen atom, an amino acid group or a peptide group containing 2 to 20 amino acid groups, and reacting it with a carrier in the presence of a binding agent for binding the hapten and the carrier to each other. Also, a process for preparing a gut glucagon antibody, which comprises administering the antigen described to mammals, and collecting the thus-produced antibody, is disclosed.