247904-63-8Relevant articles and documents
SYNTHETIC METHOD
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Page/Page column 22-23, (2010/02/10)
A quinazolin-4-one derivative of formula (I), may be made by a process including the step of cyclization an amide of formula (II), to form a quinazolin-4-one derivative of formula (III).
Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors
Marsham, Peter R.,Wardleworth, J. Michael,Boyle, F. Thomas,Hennequin, Laurent F.,Kimbell, Rosemary,Brown, Melody,Jackman, Ann L.
, p. 3809 - 3820 (2007/10/03)
The synthesis is described of a series of analogues of the potent thymidylate synthase (TS) inhibitor, N-[4-[N-[(3,4-dihydr0-2,7-dimethyl-4- oxo-6-quinazolinyl)methyl]-N-prop-2-ynylamino]2-fluorobenzoyl]-L-glutamic acid (4, ZM214888), in which the glutami