247922-33-4Relevant academic research and scientific papers
Magnesiation of N-Heterocycles Using i-PrMgCl · LiCl and catalytic diisopropylamine
Nxumalo,Dinsmore
, p. 2478 - 2484 (2015)
The direct magnesiation of various N-heterocyclic compounds with i-PrMgCl · LiCl and catalytic diisopropylamine allows for preparation of 2-substituted pyrroles, imidazole, indoles, and benzimidazoles, in moderate to good yields. The magnesiated substrates canreadily undergo a Kumada-type coupling with iodo-aryls in the presence of catalytic Pd(PPh3)4.
Magnesiation Employing Grignard Reagents and Catalytic Amine. Application to the Functionalization of N-Phenylsulfonylpyrrole
Dinsmore, Andrew,Billing, David G.,Mandy, Karen,Michael, Joseph P.,Mogano, Daniel,Patil, Shivaputra
, p. 293 - 296 (2007/10/03)
(Matrix presented) N-Phenylsulfonylpyrrole 1 is magnesiated by treatment with isopropylmagnesium chloride and catalytic diisopropylamine. Reaction with various electrophiles, including palladium-catalyzed aryl- and heteroaryl cross-coupling, provides 2-su
