24794-10-3

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 5023-94-9 (Z)-N'-hydroxy-3-nitrobenzimidamide 
• 81467-53-0 C₁₁H₁₁N₃O₅ 
• 463-51-4 Ketene 
• 5023-94-9 m-nitrobenzamide oxime 

Relevant academic research and scientific papers

Method for preparation of N-pyrazolylamidoximes

A method for the preparation of N-pyrazolylamidoximes of the general formula I R1 and R2 independently represent an alkyl, aryl, or heteroaryl group, comprises reacting a 5-(β-ketoalkyl)-3-substituted-1,2,4-oxadiazoles of the general formula II with hydrazine.

Cyclization of O-Acetoacetylbenzamide Oxime Derivatives

O-Acetoacetylbenzamide oxime derivatives (2) were prepared from benzamide oxime derivatives (1) and diketene at low temperature in almost quantitative yields.Cyclization of 2 in the presence of a strong base proceeded with elimination of acetone to afford 3-aryl-1,2,4-oxadiazolin-5-one derivatives (4) in 77-95percent yields.However, in the cases of the o-, m-, and p-nitrobenzamide oxime derivatives (2f-h), the reaction proceeded with dehydration even in the presence of a strong base to afford 5-acetonyl-3-aryl-1,2,4-oxadiazole derivatives (3f-h) in moderate yields.Possible mechanisms of these cyclization are discussed.