248-02-2

Basic information

• Product Name: 5,6-(1,3-Butadiene-1,4-diyl)thiazolo[3,2-d]tetrazole
• Synonyms: 5,6-(1,3-Butadiene-1,4-diyl)thiazolo[3,2-d]tetrazole;Tetrazolo[5,1-b]benzothiazole
• CAS NO: 248-02-2
• Molecular Formula: C7H4 N4 S
• Molecular Weight: 176.1985
• Mol File: 248-02-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.77g/cm³
• Refractive Index: 1.956
• CAS DataBase Reference: 5,6-(1,3-Butadiene-1,4-diyl)thiazolo[3,2-d]tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-(1,3-Butadiene-1,4-diyl)thiazolo[3,2-d]tetrazole(248-02-2)
• EPA Substance Registry System: 5,6-(1,3-Butadiene-1,4-diyl)thiazolo[3,2-d]tetrazole(248-02-2)

Safety Data

• Hazardous Substances Data: 248-02-2(Hazardous Substances Data)

Usage

General Description

5,6-(1,3-Butadiene-1,4-diyl)thiazolo[3,2-d]tetrazole is a chemical compound with the molecular formula C7H2N6S. It is a heterocyclic compound containing a thiazole and tetrazole ring system. 5,6-(1,3-Butadiene-1,4-diyl)thiazolo[3,2-d]tetrazole has potential applications in the field of organic synthesis and materials science due to its unique structure and properties. It can be synthesized through a series of chemical reactions involving butadiene and thiazole derivatives, and is known for its high thermal stability and potential for use as an energetic material. Additionally, this compound has been studied for its potential biological activities and has shown potential as a pharmacophore for drug design and development.

InChI:InChI=1/C7H4N4S/c1-2-4-6-5(3-1)11-7(12-6)8-9-10-11/h1-4H

Upstream product

• 615-20-3 2-chlorobenzo[d][1,3]thiazole 
• 941-55-9 4-toluenesulfonyl azide 
• 39582-59-7 benzothiazol-2-yl-lithium 
• 136-95-8 2-amino-benzthiazole 
• 1123-99-5 2-iodobenzothiazole 
• 615-21-4 1,3-benzothiazol-2-ylhydrazine 
• 149-30-4 2-Mercaptobenzothiazole 

Downstream Products

• 30937-73-6 2-(3-phenyl-triazenyl)-benzothiazole 
• 20415-66-1 N-(1,3-benzothiazol-2-yl)triphenyliminophosphorane 
• 23574-92-7 2-[3-(tris-dimethylamino-λ⁵-phosphanylidene)-triaz-1-enyl]-benzothiazole 

Relevant articles and documents

Triazolbenzo[d]thiazoles: Efficient synthesis and biological evaluation as neuroprotective agents

A number of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole (1) and 2-azidobenzo[d]thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo[d]thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.

On the utility of the azido transfer protocol: Synthesis of 2- And 5-azido N-methylimidazoles, 1,3-thiazoles and N-methylpyrazole and their conversion to triazole - azole bisheteroaryls

The azido transfer procedure of heteroaryllithium and tosyl azide was used to synthesize selected 2- and 5-azidoazoles. This procedure, which is based on the fragmentation of the appropriate lithium triazene salts 1a-7a, successfully afforded 2-azido-N-methylimidazole 1, 2-azido-l,3-thiazole 2, 2-azidobenzo-1.3-thiazole 3, 5-azido-N-methylpyrazole 4, 5-azido-N- methylimidazole 6 [via 2-(trimethylsilyl)-5-azido-N-methylimidazole 5], and 5-azido-l,3-thiazole 7 (via 5-lithio-1,3-thiazole), but attempts to prepare 5-azido-2-(trimethylsilyl)-1,3-thiazole 8 from the corresponding triazene 7a failed, affording only the desilylated azide 7 in poor yield. Azidcs 1-7 underwent 1,3-dipolar cycloaddition when mixed with neat (trimethylsilyl) acetylene, giving 1-heteroaryl-4-trimethylsilyl-1,2.3-triazoles 1b-7b generally in very high yields. The Royal Society of Chemistry 2005.

Studies on Heterocyclic Compounds. Part VI: Synthesis of Bridgehead Nitrogen Triazine and Pyrimidine Heterocycles

New bridgehead nitrogen containing heterocycles such as thiazolotriazine (IVa and IVb), imidazolotriazine (IVc), triazinotriazine (IVd and IVe) and oxadiazolotriazine (IVf) and several of their derivatives (V) have been prepared by reacting their respective hydrazine (II) with ethylpyruvate and phenyl glycoxalic acid.The diazotization of hydrazine (II) furnished the reactive intermediates (VI) (azido form) and (VII) (tetrazole form) depending on the structure of hydrazines.These intermediates have been used to synthesise bridgehead nitrogen pyrimidine derivatives (VIII) by reacting them with diethyl fumarate.The spectral and chemical evidences show that diazotised products obtained from 2-hydrazino-4-phenyl thiazole (IIa) and 2-hydrazino benzothiazole (IIb) exist in tetrazole form (VIIa) and (VIIb), respectively, whereas the remaining four (IIa-IIf) remain in the azido form (VIc-VIf) in the solid state.