24809-24-3Relevant academic research and scientific papers
D-amino acid specific proteases and native all-L-proteins: A convenient combination for semisynthesis
Wehofsky, Nicole,Pech, Andreas,Liebscher, Sandra,Schmidt, Stephanie,Komeda, Hidenobu,Asano, Yasuhisa,Bordusa, Frank
supporting information; experimental part, p. 5456 - 5460 (2009/03/12)
(Figure Presented) Side reactions side-stepped: A D-amino acid specific protease was used for the first time in the chemoenzymatic synthesis of a native protein, the peptidyl prolyl cis/trans isomerase parvulin 10 from E. coli (see scheme). Side reactions that complicate synthesis with L-amino acid specific enzymes are avoided in this approach.
