248270-23-7

Basic information

• Product Name: 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE
• Synonyms: RARECHEM AL BP 0386;1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE;2-(4-bromo-2-fluorophenyl)-1,3-dioxolane
• CAS NO: 248270-23-7
• Molecular Formula: C₉H₈BrFO₂
• Molecular Weight: 247.06
• Mol File: 248270-23-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 261.727°C at 760 mmHg
• Flash Point: 134.392°C
• Appearance: /
• Density: 1.59g/cm³
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE(248270-23-7)
• EPA Substance Registry System: 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE(248270-23-7)

Safety Data

• Hazardous Substances Data: 248270-23-7(Hazardous Substances Data)

Usage

Description

1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE is a chemical compound characterized by its molecular formula C8H6BrFO2. It is a substituted benzene derivative that incorporates a bromine, fluorine, and a 1,3-dioxolan-2-yl moiety. 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE is distinguished by its unique reactivity and properties due to the presence of these functional groups, which make it a versatile component in various chemical processes and applications.

Uses

Used in Organic Synthesis:
1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE is used as a building block in organic synthesis for the creation of a wide range of chemical compounds. Its unique structure allows for various chemical reactions, facilitating the synthesis of complex organic molecules.
Used as an Intermediate in Pharmaceutical Production:
In the pharmaceutical industry, 1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE is utilized as an intermediate. It plays a crucial role in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used as an Intermediate in Agrochemical Production:
Similarly, in the agrochemical sector, this compound serves as an intermediate in the production process. It aids in the synthesis of agrochemicals that are essential for agricultural applications, such as pesticides and herbicides.
Used in the Creation of Chemicals and Materials:
1-BROMO-4-(1,3-DIOXOLAN-2-YL)-3-FLUOROBENZENE is also used as a building block in the creation of various other chemicals and materials across different industries. Its unique properties make it a valuable component in the development of new materials with specific characteristics required for specialized applications.

InChI:InChI=1/C9H8BrFO2/c10-6-1-2-7(8(11)5-6)9-12-3-4-13-9/h1-2,5,9H,3-4H2

Upstream product

• 107-21-1 ethylene glycol 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 913739-13-6 di-tert-butyl (3-fluoro-4-formylphenyl)(methyl)malonate 
• 913739-12-5 di-tert-butyl [4-(1,3-dioxolan-2-yl)-3-fluorophenyl](methyl)malonate 
• 913739-20-5 ethyl 6-{[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]methyl}-1-benzothiophene-2-carboxylate 
• 913739-18-1 ethyl 6-{2-[2-(4-methoxybenzoyl)hydrazino]-2-oxoethyl}-1-benzothiophene-2-carboxylate 
• 913739-11-4 di-tert-butyl [4-(1,3-dioxolan-2-yl)-3-fluorophenyl]malonate 
• 699016-40-5 2-fluoro-4-iodobenzaldehyde 

Relevant articles and documents

FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE

The present invention relates to a fused tricyclic compound and use thereof as a medicament, in particular as a medicament for the treatment and/or prevention of hepatitis B. Specifically, the invention relates to a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variate is as defined in specification. The invention also relates to the use of the compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.

BENZOTHIOPHENE DERIVATIVES

The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of the hydroxamic acid derivatives in vivo.

Aminoalcohol derivatives

The present invention relates to a compound formula [I]: wherein R1 is hydrogen or halogen, R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, X is bond, —CH2— or —O—, and Y is ?in which R4 is lower alkoxycarbonyl, ?in which R5 is carboxy(lower)alkyl, etc., ?in which R6 is hydroxy, etc., and so on, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.