248275-99-2Relevant academic research and scientific papers
In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (-)-cytisine
Coe, Jotham W.,Vetelino, Michael G.,Bashore, Crystal G.,Wirtz, Michael C.,Brooks, Paige R.,Arnold, Eric P.,Lebel, Lorraine A.,Fox, Carol B.,Sands, Steven B.,Davis, Thomas I.,Schulz, David W.,Rollema, Hans,Tingley III, F. David,O'Neill, Brian T.
, p. 2974 - 2979 (2007/10/03)
The preparation and biological activity of analogs of (-)-cytisine, an α4β2 nicotinic receptor partial agonist, are discussed. All-carbon-containing phenyl ring replacements of the pyridone ring system, generated via Heck cyclization protocols, exhibited
Nicontinic acetylcholine receptor antagonists in the treatment of restless legs syndrome
-
, (2008/06/13)
This invention relates to the use of nicotinic acetylcholine receptor agonists for the treatment of restless legs syndrome (RLS). The invention further relates to the use of a nicotinic acetylcholine receptor agonist in the manufacture of a medicament for the treatment of RLS. The present invention also relates to a pharmaceutical composition for the treatment of RLS containing a nicotinic acetylcholine receptor agonist.
