24836-98-4

Usage

Class

Organic compounds, specifically ketoesters

Appearance

Yellow liquid

Usage

Precursor in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Chemical structure

Contains a cyclohexane ring with two ketone groups and a butyl group attached

Safety precautions

Potential health and environmental hazards require careful handling.

Upstream product

• 218934-50-0 2-ethyl-1,5,6,7-tetrahydro-1-(phenylmethyl)-4H-indol-4-one 
• 100-46-9 benzylamine 
• 504-02-9 1,3-cylohexanedione 
• 816-40-0 1-Bromo-2-butanone 
• 616-27-3 1-chlorobutan-2-one 

Downstream Products

• 218934-50-0 2-ethyl-1,5,6,7-tetrahydro-1-(phenylmethyl)-4H-indol-4-one 

Relevant academic research and scientific papers

Urea decomposition: Efficient synthesis of pyrroles using the deep eutectic solvent choline chloride/urea

A simple and efficient method is reported for the synthesis of pyrroles via condensation of a series of tricarbonyl compounds with ammonia, which was generated in situ from decomposition of the deep eutectic solvent choline chloride/urea.

Understanding the Scope of Feist–Bénary Furan Synthesis: Chemoselectivity and Diastereoselectivity of the Reaction Between α-Halo Ketones and β-Dicarbonyl Compounds

Feist–Bénary furan synthesis, the reaction between α-halocarbonyl and β-dicarbonyl compounds, has been known as an efficient method for generating many different types of furans containing a carbonyl group at C-3. However, it has also been reported that, under similar reaction conditions, intermediate tricarbonyl species could be further converted to alternative furan isomers through the application of a Paal–Knorr synthesis. In this manuscript, we investigate the chemoselectivity and diastereoselectivity of furan synthesis from α-halo ketones and β-dicarbonyl compounds, by carrying out the separation and characterization of the intermediates involved in the reaction. Additionally, a one-pot Feist–Bénary furan synthesis from α-halo ketones and β-dicarbonyl compounds without any base or solvent has also been developed.

Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists

A series of novel indazole derivatives were synthesized, and their structure-activity relationships examined in order to identify potent and selective 5-HT2C receptor agonists. Among these compounds, (S)-2-(7-ethyl-1H-furo[2,3-g]indazol-1-yl)-1-methylethylamine (YM348) had a good in vitro profile, that is, high agonistic activity to the human 5-HT2C receptor subtype (EC50 = 1.0 nM) and high selectivity over 5-HT2A receptors. This compound was also effective in a rat penile erection model when administered po.

Process for preparing 4-hdyroxy indole, indazole and carbazole compounds

A process for preparing 4-hydroxy carbazoles useful as intermediates for preparing compounds that are useful for inhibiting sPLA2and novel intermediates.

Process for preparing 4-substituted-1h-indole-3-glyoxamides

A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2and novel intermediates useful in the preparation of such compounds.

Process for preparing 4-substituted-1H-indole-3-glyoxamides

A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.

Process for preparing 4-substituted-1H-indole-3-glyoxamides

A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.