24849-50-1

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-4-[4-(acetylamino)phenyl]-4-oxobut-2-enoic acid is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its structural features and functional groups make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (2E)-4-[4-(acetylamino)phenyl]-4-oxobut-2-enoic acid serves as a key component in the design and synthesis of novel molecules with potential therapeutic properties. Ongoing research aims to explore its biological and chemical properties to unlock its full potential in future drug development.

Upstream product

• 108-31-6 maleic anhydride 
• 103-84-4 Acetanilid 

Downstream Products

• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 
• 1218788-68-1 C₁₈H₁₅NO₆ 
• 1218788-64-7 C₁₈H₁₅NO₅ 
• 1218788-66-9 C₁₈H₁₅NO₅ 
• 1218788-62-5 γ-(4-acetamidophenyl)-γ-(2,4-dihydroxyphenyl)-Δα,β-butenolide, 
• 1218788-70-5 C₁₈H₁₅NO₆ 
• 1218788-60-3 C₁₈H₁₅NO₄ 

Relevant academic research and scientific papers

Synthesis and applications of pyridazinones for base oil improvement

THREE pyridazinone derivatives of the type 4,5-dihydropyridazin- 3(2H)-ones, N-(4-(6-oxo-5- ((5-phenyl-1,3,4-thiadiazol-2-yl)amino) - 1,4,5,6 - tetrahydropyridazin - 3-yl) phenyl) acetamide (4a), 6-(4-chlorophenyl)-4-((5-phenyl-1,3,4-thiadiazol-2-yl)amino)-4,5-di-hydropyridazin-3 (2H)-one (4b) and 6-(4-bromophenyl) -4- ((5-phenyl-1,3,4-thiadiazol-2-yl) amino)-4,5-dihydropyridazin-3(2H)-one (4c) were synthesized. They were characterized by the conventional tools of analysis, Elemental analysis, IR and 1H-NMR spectroscopy. The tools of analysis confirmed the structure of the three prepared compounds. These heterocyclic compounds are chemically stable and possess multi actions for base oil improvement. They are tested as antioxidants for local base oil through the change in total acid number (TAN). They gave good results as antioxidants for base oil. Also these three synthesized compounds are tested as corrosion inhibitors for carbon steel in acid medium. The efficiency order for these tested compounds is ranked as follows: 4a > 4b > 4c. Energy of the highest occupied molecular orbital (EHOMO) and lowest unoccupied molecular orbital (ELUMO) for the three prepared compounds were calculated via the Ab initio method. Studying of the quantum chemical calculations of the synthesized compounds showed good matching with the experimental results.

Utility of p-acetamidobenzoyl prop-2-enoic acid in the synthesis of new α-amino acids and using them as building blocks in heterocyclic synthesis

THE PRESENT work deals with the generation and synthesis of different unnatural amino acid derivatives via treatment of 3-(4-acetamidobenzoyl)-prop-2- enoic acid with 5-aryl-2-amino 1,3, 4 thiadiazole, 3,5-dimethyl pyrazole and barbituric acid to afford t

3-(Benzoyl)oxiranecarboxamides

Novel trans-isomers of 3-(benzoyl)oxiranecarboxamides, useful as lipogenesis inhibitors in warm-blooded animals.