24856-00-6Relevant articles and documents
Wide-Range Near-Infrared Sensitizing 1 H -Benzo [c, d] indol-2-ylidene-Based Squaraine Dyes for Dye-Sensitized Solar Cells
Haishima, Yuki,Kubota, Yasuhiro,Manseki, Kazuhiro,Jin, Jiye,Sawada, Yoshiharu,Inuzuka, Toshiyasu,Funabiki, Kazumasa,Matsui, Masaki
, p. 4389 - 4401 (2018)
NIR absorbing squaraine dyes SQ1-SQ7 having 1H-benzo[c,d]indol-2-ylidene as a donor moiety were designed for application in DSSCs. Annulation of the benzene ring to an 3H-indolium-based anchor moiety led to a red-shifted and broadened absorption band on TiO2 film, which were reflected in the improved short-circuit current density of SQ2 (6.22 mA cm-2) compared to the nonbenzene fused derivative SQ1 (4.39 mA cm-2). Although the introduction of a butoxy (SQ4: 806 nm) or dialkylamino group (SQ5-SQ7: 815-820 nm) to the 1H-benzo[c,d]indol-2-ylidene-based donor moiety resulted in red-shifted absorption maxima in ethanol compared to the nonsubstituted derivative SQ2 (784 nm), the HOMO energy level of SQ4-SQ7 gave rise to an undesirable approximation to the redox potential of I-/I3-. Thus, the butoxy (SQ4: 0.56) and dialkylamino (SQ5-SQ7: 0.25-0.30) derivatives had relatively lower conversion efficiencies. Since the 2-ethylhexyl derivative SQ3 exhibited red-shifted absorption (λmax: 796 nm), suitable HOMO and LUMO energy levels, and relatively efficient restriction of charge recombination, this dye achieved the highest conversion efficiency (1.31%), along with a high IPCE response of over 20% over a wide range from 640 to 860 nm and an onset of IPCE at 1000 nm.
Y06014 is a selective BET inhibitor for the treatment of prostate cancer
Wu, Tian-bang,Xiang, Qiu-ping,Wang, Chao,Wu, Chun,Zhang, Cheng,Zhang, Mao-feng,Liu, Zhao-xuan,Zhang, Yan,Xiao, Lin-jiu,Xu, Yong
, p. 2120 - 2131 (2021/03/15)
Bromodomain and extra-terminal proteins (BETs) are potential targets for the therapeutic treatment of prostate cancer (PC). Herein, we report the design, the synthesis, and a structure?activity relationship study of 6-(3,5-dimethylisoxazol-4-yl)benzo[cd]indol-2(1H)-one derivative as novel selective BET inhibitors. One representative compound, 19 (Y06014), bound to BRD4(1) in the low micromolar range and demonstrated high selectivity for BRD4(1) over other non-BET bromodomain-containing proteins. This molecule also potently inhibited cell growth, colony formation, and mRNA expression of AR-regulated genes in PC cell lines. Y06014 also shows stronger activity than the second-generation antiandrogen enzalutamide. Y06014 may serve as a new small molecule probe for further validation of BET as a molecular target for PC drug development.
TRICYCLIC DEGRADERS OF IKAROS AND AIOLOS
-
Page/Page column 237-238; 373; 461; 545-546; 549-550, (2020/10/21)
Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.
