248595-06-4Relevant academic research and scientific papers
Synthesis of 2, 5-disubstituted 1, 3, 4-oxadiazoles as biologically active heterocycles
Kagthara, Preeti R.,Shah, Niraj S.,Doshi, Rajeev K.,Parekh
, p. 572 - 576 (2007/10/03)
2-(Benzimidazol-2'-yl) benzoyl hydrazide 1 when condensed with aromatic acids in the presence of POCl3 afforded 2-aryl-5-[2'-benzimidazol-2''-yl) phenyl]-1, 3, 4-oxadiazoles 2a-o. The acid hydrazide 1 on cyclisation with CNBr yield 2-amino-5-[2'-(benzimidazol-2''-yl-phenyl)-1, 3, 4-oxadiazole 3 which on reaction with aryl sulphonyl chlorides and substituted benzoyl chloride give the corresponding sulphonamides 4a-o and amides 5a-o, respectively. All the products have been evaluated in vitro for their antimicrobial activity against several microbes and antitubercular activity against Mycobacterium tuberculosis H37Rv.
