2486-84-2Relevant academic research and scientific papers
Synthesis and supramolecular features of hybrid POM/onium solid-state assemblies
Talotta, Carmen,Rubino, Luca,Gaeta, Carmine,Capitelli, Francesco,Saviano, Michele,Brancatelli, Giovanna,Geremia, Silvano,Vasca, Ermanno,Neri, Placido
, p. 403 - 417 (2016/04/19)
Polyoxomolybdate-based organic-inorganic hybrid architectures were synthesised and characterised by X-ray crystallography. The supramolecular assemblies present rows of metallic clusters H-bonded by ammonium cations, with a 1:2 molybdate/ammonium ratio. The organic moieties of the ammonium cations establish hydrophobic contact among them such as van der Waals, C-Hπ and ππ interactions that stabilise the supramolecular architectures. In particular, for compound 5 the n-alkyl tails pack closely together giving a lipid-like bilayer. In compound 6, the aromatic phenyl rings of the organic cation allow the stabilisation of the supramolecular architecture by C-Hπ and ππ interactions. Regarding the X-ray structure of the compound 11, the tetraanionic octa-molybdate [Mo8O26]4- cluster is surrounded by four ethyl-triphenyl-phosphonium cations. Running along the b-axis open channels are occupied by DMF solvent molecules. Interestingly, a soaking experiment in n-pentane with the corresponding crystals of compound 11 afforded to a crystal structure very different from the native one. Van der Waals, C-Hπ and ππ interactions between large organic moieties are fundamental in the stabilization of hybrid organic-inorganic POM architectures.
Designing Simple Lipidated Lysines: Bifurcation Imparts Selective Antibacterial Activity
Ghosh, Chandradhish,Konai, Mohini Mohan,Sarkar, Paramita,Samaddar, Sandip,Haldar, Jayanta
supporting information, p. 2367 - 2371 (2016/11/13)
In the global effort to thwart antimicrobial resistance, lipopeptides are an important class of antimicrobial agents, especially against Gram-negative infections. In an attempt to circumvent their synthetic complexities, we designed simple membrane-active agents involving only one amino acid and two lipid tails. Herein we show that the use of two short lipid tails instead of a single long one significantly increases selective antibacterial activity. This study yielded several selective antibacterial compounds, and investigations into the properties of this compound class were conducted with the most active compound. Fluorescence spectroscopic studies revealed the capacity of the representative compound to cause depolarization and permeabilization of bacterial cell membranes. This membrane-active nature of the compound imparts superior activity against persister cells, biofilms, and planktonic cells. Topical application of the compound decreased bacterial burden in mice inflicted with burn-infections caused by Acinetobacter baumannii. We anticipate that the design principles described herein will direct the development of several antimicrobial agents of clinical importance.
