248601-94-7Relevant academic research and scientific papers
Total Synthesis of Squamotacin
Sinha, Santosh C.,Sinha, Subhash C.,Keinan, Ehud
, p. 7067 - 7073 (2007/10/03)
The first total synthesis of (+)-squamotacin, 1, which has shown cytotoxic selectivity for the human prostate tumor cell line, was achieved in 27 steps and 0.83% yield starting with (+)-muricatacin, 4. All asymmetric centers in the bistetrahydrofuran fragment of the molecules were produced by the Sharpless asymmetric dihydroxylation (AD) and the asymmetric epoxidation (AE) reactions.
