248602-63-3

Basic information

• Product Name: (E)-phenyl-2-dimethylphosphono-3-acetic acid acid ethyl ester
• Synonyms: (E)-phenyl-2-dimethylphosphono-3-acetic acid acid ethyl ester
• CAS NO: 248602-63-3
• Molecular Weight: 254.222
• Mol File: 248602-63-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-phenyl-2-dimethylphosphono-3-acetic acid acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-phenyl-2-dimethylphosphono-3-acetic acid acid ethyl ester(248602-63-3)
• EPA Substance Registry System: (E)-phenyl-2-dimethylphosphono-3-acetic acid acid ethyl ester(248602-63-3)

Safety Data

• Hazardous Substances Data: 248602-63-3(Hazardous Substances Data)

Upstream product

• 868-85-9 Dimethyl phosphite 
• 1896-62-4 (E)-benzalacetone 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 4202-14-6 dimethyl (2-oxopropyl)phosphonate 
• 6425-08-7 4,4'-(phenylmethylene)bismorpholine 

Relevant articles and documents

Silver-catalyzed direct regioselective phosphonation of β-aryl-α, β-unsaturated carbonyl compounds with H-phosphites under microwave irradiation

An efficient protocol for silver-catalyzed direct radical phosphonation of β-aryl-α,β-unsaturated carbonyl compounds with H-phosphites to afford trans-substituted alkenylphosphonates under microwave irradiation is described. Some notable features of this

Hetero-Diels-Alder reactions of α-carbonylated styrylphosphonates with enol ethers. High-pressure influence on reactivity and diastereoselectivity

Variously substituted α-carbonylated styrylphosphonates 5 were easily prepared by Knoevenagel-type syntheses, and used as oxadienes in hetero-Diels-Alder [4 + 2] cycloadditions with enol ethers, to give new phosphonylated 3,4-dihydro-2H-pyrans 6. It was confirmed that the reactivity, as well as the trans-diastereoselectivity of the reaction, was significantly enhanced by the use of high-pressure conditions, particularly in the presence of ButOH as a co-solvent. Moreover, a one-pot synthesis of 6 via a tandem-sequence Knoevenagel and hetero-Diels-Alder reactions was achieved.