248602-63-3Relevant academic research and scientific papers
Method for preparing (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative
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Paragraph 0046; 0047; 0048; 0049, (2016/10/10)
The invention discloses a method for preparing a (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative (I) (please the formula in the description), and belongs to the field of organic chemistry. According to the method, a 2-aryl-alpha, beta-unsaturated carbonyl compound and phosphite ester serve as raw materials and react with tetrahydrofuran (THF) and other materials as a solvent under the combined action of AgNO3 catalyzing and an assistant agent at the temperature of 20-80 DEG C, and then the (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative is obtained. According to the method, the 2-aryl-alpha, beta-unsaturated carbonyl compound serves as the initial raw material, the raw materials are low in price and easy to obtain, reaction conditions are mild, operation is easy and convenient, the synthesis yield is high, and industrial production is facilitated. The derivative has potential application in chemical engineering, medicine, cosmetics and other fields, and a new approach is provided for synthesis of the (E)-2-aryl-alpha, beta-unsaturated carbonyl phosphonate derivative.
Silver-catalyzed direct regioselective phosphonation of β-aryl-α, β-unsaturated carbonyl compounds with H-phosphites under microwave irradiation
Yuan, Jin-Wei,Li, Yuan-Zhe,Mai, Wen-Peng,Yang, Liang-Ru,Qu, Ling-Bo
, p. 3084 - 3091 (2016/05/19)
An efficient protocol for silver-catalyzed direct radical phosphonation of β-aryl-α,β-unsaturated carbonyl compounds with H-phosphites to afford trans-substituted alkenylphosphonates under microwave irradiation is described. Some notable features of this
Hetero-Diels-Alder reactions of α-carbonylated styrylphosphonates with enol ethers. High-pressure influence on reactivity and diastereoselectivity
Al-Badri, Hashim,Maddaluno, Jacques,Masson, Serge,Collignon, Noel
, p. 2255 - 2266 (2007/10/03)
Variously substituted α-carbonylated styrylphosphonates 5 were easily prepared by Knoevenagel-type syntheses, and used as oxadienes in hetero-Diels-Alder [4 + 2] cycloadditions with enol ethers, to give new phosphonylated 3,4-dihydro-2H-pyrans 6. It was confirmed that the reactivity, as well as the trans-diastereoselectivity of the reaction, was significantly enhanced by the use of high-pressure conditions, particularly in the presence of ButOH as a co-solvent. Moreover, a one-pot synthesis of 6 via a tandem-sequence Knoevenagel and hetero-Diels-Alder reactions was achieved.
