248607-86-5Relevant academic research and scientific papers
Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity
Jarvest, Richard L.,Berge, John M.,Brown, Pamela,Houge-Frydrych, Catherine S. V.,O'Hanlon, Peter J.,McNair, David J.,Pope, Andrew J.,Rittenhouse, Stephen
, p. 1265 - 1268 (2007/10/03)
Conformationally restricted analogues of the central linker unit of bacterial methionyl tRNA synthetase (MRS) inhibitors have been prepared. The (1S,2R)-cyclopentylmethyl moiety was identified as the preferred cyclic linker, with significant diastereo- and enantioselectivity of activity. Combination of this linker with an optimal substituted aryl right-hand side has resulted in a compound with exceptionally good antibacterial activity against staphylococci and enterococci, including antibiotic resistant strains.
