24864-42-4

Upstream product

• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 13404-22-3 tert-butyl L-alaninate hydrochloride 

Downstream Products

• 144923-65-9 N-benzyloxycarbonyl-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-seryl-alanine tert-butyl ester 
• 144923-66-0 N-benzyloxycarbonyl-alanyl--seryl-alanine tert-butyl ester 
• 144923-60-4 N-benzyloxycarbonyl-O-<3,4,6-tri-O-acetyl-2-(N-2,2,2-trichloroethyloxycarbonyl)-amino-2-deoxy-β-D-glucopyranosyl>-seryl-alanine tert-butyl ester 
• 144923-63-7 N-benzyloxycarbonyl-O-(3,4,6-tri-O-acetyl-2-N-allyloxycarbonylamino-2-deoxy-β-D-glucopyranosyl)-seryl-alanine tert-butyl ester 

Relevant academic research and scientific papers

Diboronic Acid Anhydride-Catalyzed Direct Peptide Bond Formation Enabled by Hydroxy-Directed Dehydrative Condensation

We report the catalytic direct peptide bond formations via dehydrative condensation of β-hydroxy-α-amino acids, affording the serine, threonine, or β-hydroxyvaline-derived peptides in high to excellent yields with high functional group tolerance, minimum epimerization, and excellent chemoselectivity. The key to the success of these atom-economical transformations is the use of diboronic acid anhydride catalyst for the hydroxy-directed reactions.