24866-79-3Relevant academic research and scientific papers
Transition-metal-based Lewis acid and base ambiphilic catalysts of iridium hydride complexes: Multicomponent synthesis of glutarimides
Takaya, Hikaru,Yoshida, Kazunori,Isozaki, Katsuhiro,Terai, Hiroki,Murahashi, Shun-Ichi
, p. 3302 - 3304 (2007/10/03)
Mutual destruction of reagents in acid-and base-promoted reactions in the same container is now avoidable with the iridium polyhydride complex [IrH5(PiPr3)2] (1), which is an ambiphilic Lewis acid and base catalyst. By using catalyst 1, a three-component reaction of nitriles, olefins, and water proceeds efficiently to give glutarimides, which are pharmacologically important (see scheme).
Synthesis and anticonvulsant activity of 2-benzylglutarimides
Goehring,Greenwood,Nwokogu,Pisipati,Rogers,Wolfe
, p. 926 - 931 (2007/10/02)
A series of 2-benzylglutarimides (4) and their N-methyl analogues (5) were prepared according to the Topliss scheme for the selection of benzyl substituents to maximize anticonvulsant activity. A total of 22 such compounds were subjected to initial (phase
