248937-25-9Relevant academic research and scientific papers
A simple and efficient diastereoselective Strecker synthesis of optically pure α-arylglycines
Dave, Rajesh H.,Hosangadi, Bhaskar D.
, p. 11295 - 11308 (2007/10/03)
A simple and economical method for the synthesis of highly functionalised α-amino nitriles, precursors to α-arylglycines with high optical purity is reported. For this purpose, (R) or (S)-2-amino-2- phenylethanol were used as chiral auxiliaries in a 1,3 Strecker reaction. Reactions were studied with a broad range of reagent systems for the generation of cyano nucleophile. Methodology has been extended for the synthesis of (S)-α-(2-iodo-5-nitrophenyl)glycine, (S)-α-(4- methoxyphenyl)glycine and (R)-β-(4-methoxyphenyl)alanine.
