248937-28-2

Basic information

• Product Name: (R,S)-2-[(2-hydroxy-1-phenylethyl)amino]-2-(1-naphthyl)ethanenitrile
• CAS NO: 248937-28-2
• Molecular Weight: 302.376
• Mol File: 248937-28-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,S)-2-[(2-hydroxy-1-phenylethyl)amino]-2-(1-naphthyl)ethanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-2-[(2-hydroxy-1-phenylethyl)amino]-2-(1-naphthyl)ethanenitrile(248937-28-2)
• EPA Substance Registry System: (R,S)-2-[(2-hydroxy-1-phenylethyl)amino]-2-(1-naphthyl)ethanenitrile(248937-28-2)

Safety Data

• Hazardous Substances Data: 248937-28-2(Hazardous Substances Data)

Upstream product

• 66-77-3 1-naphthaldehyde 
• 20989-17-7 (2S)-2-phenylglycinol 
• 143-33-9 sodium cyanide 

Downstream Products

• 100896-07-9 (R)-α-(1-naphthyl)glycine 

Relevant articles and documents

A simple and efficient diastereoselective Strecker synthesis of optically pure α-arylglycines

A simple and economical method for the synthesis of highly functionalised α-amino nitriles, precursors to α-arylglycines with high optical purity is reported. For this purpose, (R) or (S)-2-amino-2- phenylethanol were used as chiral auxiliaries in a 1,3 Strecker reaction. Reactions were studied with a broad range of reagent systems for the generation of cyano nucleophile. Methodology has been extended for the synthesis of (S)-α-(2-iodo-5-nitrophenyl)glycine, (S)-α-(4- methoxyphenyl)glycine and (R)-β-(4-methoxyphenyl)alanine.