24911-17-9Relevant academic research and scientific papers
Regioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds
McLaughlin, Mark G.,Roberts, Dean D.
, p. 4463 - 4467 (2021)
We describe, for the first time, a highly regioselective hydrosilylation of propargylic amines. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The reaction is tolerant to a wide variety of functional groups and provides high value intermediates with two distinct functional handles. The synthetic applicability of the reaction has been shown through the synthesis of diverse ambiphilic aziridines.
Synthesis and bioactivities of novel N-(4-(2-Aryloxythiazol-5-yl)but-3-yn- 2-yl)benzamides
Zhu, Youquan,Liu, Pei,Wang, Danyang,Zhang, Jin,Cheng, Jie,Ma, Yuan,Zou, Xiaomao,Yang, Huazheng
, p. 173 - 181 (2013/08/24)
A series of novel N-(4-(2-aryloxythiazol-5-yl)but-3-yn-2-yl)benzamide derivatives were designed and synthesized. Their structures were identified by 1H NMR and elemental analyses. Preliminary bioassays indicated that some title compounds provided >80% control of Sclerotinia sclerotiorum at 50 μg/mL and >70% herbicidal activities against B. campestris at 100 μg/mL. Their structure-activities relationships were also discussed. A series of novel N-(4-(2-aryloxythiazol-5-yl)but-3-yn-2-yl)benzamide derivatives were designed and synthesized. Some of them provided >80% control of Sclerotinia sclerotiorum at 50 μg/mL and >70% herbicidal activities against B. campestris at 100 μg/mL. Copyright
