24955-20-2Relevant academic research and scientific papers
Stereocontrolled synthesis of erythro N-protected α-amino epoxides and peptidyl epoxides
Albeck, Amnon,Persky, Rachel
, p. 6333 - 6346 (2007/10/02)
N-protected α-amino epoxides of erythro configuration, derived from α-amino acids, were synthesized in a stereoselective manner. The erythro (2S,3S), configuration was achieved by the synthetic sequence: amino acid -> haloketone -> halohydrin -> epoxide. A mechanistic explanation for the observed stereoselectivity is presented. This stereoselective synthetic approach was applied to the synthesis of a variety of short peptidyl epoxides, bearing a predefined absolute configuration of the chiral epoxide moiety.
INVESTIGATION ON COUPLING PEPTIDES TO AMINOMETHYL POLYMERS
Orlowska, Alicja,Drabarek, Stefania
, p. 2329 - 2336 (2007/10/02)
Different peptide bond forming methods for attachment of model peptides to aminomethyl polymers have been compared.It has been observed that the yield of reaction depends on such features of polymer as quantity of functional groups and degree of its cross-linking.The sequential Edman degradation of a model peptide corresponding to 5 to 9 fragment of substance P was performed by the solid-phase technique.
