249613-09-0Relevant articles and documents
Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1' substituents
Kaltenbach III, Robert F.,Klabe, Ronald M.,Cordova, Beverly C.,Seitz, Steven P.
, p. 2259 - 2262 (2007/10/03)
A series of alkyl substituted P1/P1' analogs was prepared in an attempt to increase translation of the 3-aminoindazole class of HIV protease inhibitors. Increasing the lipophilicity of the P1/P1' residues dramatically improved translation of enzyme activity to antiviral activity in the whole cell assay.
