249630-49-7Relevant academic research and scientific papers
Synthesis and supramolecular properties of a novel octaphosphonate porphyrin
Bhosale, Sheshanath V.,Kalyankar, Mohan B.,Langibrd, Steven J.,Bhosale, Sidhanath V.,Oliver, Ruth F.
experimental part, p. 4128 - 4134 (2009/12/26)
Two complementary routes were developed for preparing novel octaphosphonate porphyrins. The use of protected/deprotected phosphonate-substituted precursors in the rational synthesis gave an overall yield 16%. A more streamlined synthetic path gave 21 % overall yield, of the target molecule. Octaphosphonate porphyrin possesses promising properties in supramolecular aggregate formation with cyclam. Cofacial reversible self-assembly of a meso-substituted octaphosphonate porphyrin with cyclam yields micrometer-long nanowires with a height of about 1-1.5 nm. The resulting wires were characterized by UV/Vis absorption, emission and atomic force microscopy and transmission electron microscopy. ( Wiley-VCH Verlag GmbH & Co. KGaA.
Synthesis of nuclease-resistant siRNAs possessing benzene-phosphate backbones in their 3′-overhang regions
Ueno, Yoshihito,Inoue, Takumi,Yoshida, Mahito,Yoshikawa, Kayo,Shibata, Aya,Kitamura, Yoshiaki,Kitade, Yukio
scheme or table, p. 5194 - 5196 (2009/05/07)
We describe the synthesis and silencing activities of siRNA possessing N1-[3,5-bis(hydroxymethyl)phenyl]thymine (bt) in their 3′-overhang regions. We found that an siRNA possessing bt in the 3′-overhang region was more effective than an siRNA with natural nucleosides and the siRNA possessing 1,3-bis(hydroxymethyl)benzene (b) without a nucleobase at the 3′-overhang region in in vitro experiment using HeLa cells system. Furthermore, the RNA possessing bt at its 3′-end was more resistant to nucleolytic hydrolysis by snake venom phosphodiesterase (a 3′-exonuclease) than the RNA possessing the natural nucleoside 2′-deoxythymidine at the 3′-end. Thus, the compound bt will be a novel 3′-overhang moiety that can enhance the silencing activity and nuclease-resistant property of siRNAs.
Modular Approach to the Accelerated Convergent Growth of Laser Dye-Labeled Poly(aryl ether) Dendrimers Using a Novel Hypermonomer
Gilat, Sylvain L.,Adronov, Alex,Frechet, Jean M. J.
, p. 7474 - 7484 (2007/10/03)
The synthesis of novel dendrimers functionalized with laser dyes both at the periphery and at the core, along with all relevant model compounds necessary for accurate photophysical studies, is described. The utilized synthetic strategy involves a modular approach in which a variety of peripheral and core moieties can be placed on a dendritic structure bearing electrophilic peripheral groups and a nucleophilic core. Specifically, the target macromolecules required functionalization with the laser dyes coumarin 2 (periphery) and coumarin 343 (core) due to the possibility of energy transfer from the former to the latter dye. In addition, the preparation of a novel, highly soluble and reactive hypermonomer utilized in the rapid and efficient synthesis of high-generation dye-labeled dendrimers and model compounds is outlined.
