24966-31-2

Usage

Derivative of benzodioxole

A derivative is a compound that is structurally similar to another compound, from which it is derived. In this case, MDBPAN is derived from benzodioxole.

Nitrile compound

MDBPAN contains a nitrile group (C≡N), which is a functional group consisting of a carbon atom triple-bonded to a nitrogen atom.

Ketone functional group

MDBPAN also contains a ketone group (C=O), which is a functional group consisting of a carbon atom double-bonded to an oxygen atom.

Organic synthesis and pharmaceutical research

MDBPAN is often used as a building block for the production of other compounds in these fields, making it a valuable intermediate.

Potential applications

The compound has potential applications in the development of new drugs and in medicinal chemistry, due to its unique chemical structure.

Valuable intermediate

MDBPAN's unique chemical structure makes it a valuable intermediate in the synthesis of various organic compounds, as it can be used to create a wide range of other compounds.

Upstream product

• 4439-02-5 3,4-methylenedioxyphenylacetonitrile 
• 109-94-4 formic acid ethyl ester 
• 133218-07-2 3-(3,4-methylenedioxyphenyl)-1-propyne 

Relevant academic research and scientific papers

Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase

A combination of focused library and virtual screening, hit expansion, and rational design has resulted in the development of a series of inhibitors of RETV804M kinase, the anticipated drug-resistant mutant of RET kinase. These agents do not inhibit the wild type (wt) isoforms of RET or KDR and therefore offer a potential adjunct to RET inhibitors currently undergoing clinical evaluation.

7-Aminopyrazolo[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors

7-Aminopyrazolo[1,5-a]pyrimidine urea receptor tyrosine kinase inhibitors have been discovered. Investigation of structure-activity relationships of the pyrazolo[1,5-a]pyrimidine nucleus led to a series of 6-(4-N,N′-diphenyl) ureas that potently inhibited

Potential antimalarials. XXII Some 2,4-diamino-5-(3- and 4-trifluoromethylphenyl and 3,4-methylenedioxyphenyl)pyrimidines

A series of 10 pyrimethamine analogues containing 3′- and 4′-trifluoromethyl and 3′,4′-methylenedioxy groups has been prepared and tested for in vitro antimalarial activity against the FC-27 and K-1 isolates of Plasmodium falciparum. Several of these compounds were almost as active as pyrimethamine against the drug-sensitive FC-27 isolate, and like pyrimethamine, they were much less active against the drug-resistant K-1 isolate. The 4′-trifluoromethyl compunds, however, showed much smaller differences.