24966-37-8Relevant academic research and scientific papers
Different reactivity of hydroxylamine with carbamoyl azides and carbamoyl cyanides: Synthesis of hydroxyureas and carbamoyl amidoximes
Paz, Jairo,Perez-Balado, Carlos,Iglesias, Beatriz,Munoz, Luis
supporting information; experimental part, p. 8039 - 8047 (2011/02/26)
The carbamoylating agents carbamoyl azides and carbamoyl cyanides (aka cyanoformamides) react with hydroxylamine in different ways, leading in the first case to N-hydroxyureas and, in the case of carbamoyl cyanides, to carbamoyl amidoxime derivatives. The
Synthesis of substituted N-hydroxyureas via the in situ generation of t-butoxy isocyanate
Krause, Josef G.,Leskiw, Brian D.,Emery, Michelle L.,McGahan, Megan E.,McCourt, Mary P.,Priefer, Ronny
body text, p. 3568 - 3570 (2010/08/07)
Treatment of primary and secondary amines with tert- butylmesitylenesulfonoxycarbamate and a base afforded tert-butoxyurea, which when treated with an acid ultimately yielded substituted N-hydroxyureas. It is proposed that this proceeded via the generation of t-butoxy isocyanate in situ. This method allows for the synthesis of both mono and disubstituted N-hydroxyureas.
A convenient method for the synthesis of N-hydroxyureas
Parrish, Dennis A.,Zou, Zhou,Allen, C. Leigh,Day, Cynthia S.,King, S. Bruce
, p. 8841 - 8843 (2007/10/03)
Treatment of amines with 1-(4-nitrophenol)-N-(O-benzylhydroxy)carbamate yields the O-benzyl protected N-hydroxyureas. Hydrogenation of the O-benzyl protected N-hydroxyureas over 5% Pd/BaSO4 cleanly gives the N-hydroxyureas in good yield. In add
