24968-99-8Relevant articles and documents
Multi-gram preparation of cinnamoyl tryptamines as skin whitening agents through a chemo-enzymatic flow process
Padrosa, David Roura,Contente, Martina L.
, (2021/11/18)
A 2-step flow-based chemo-enzymatic synthesis of selected cinnamoyl tryptamines as potential cosmetic ingredients has been developed. A first reaction catalyzed by immobilized Pd(OAc)2 gave the acyl donors employed as starting material in the s
Palladium(II) acetate as catalyst in transvinylation reactions of hydroxycinnamic acid and its derivatives
Kadidae,Usami,Honda
, p. 589 - 593 (2018/02/09)
The study on application of palladium(II) acetate as catalyst in transvinylation reactions of hydroxycinnamic acids has been done. This study was intended to assess the capability of palladium(II) acetate as a safer replacement for mercuric(II) catalysts
Chemo-enzymatic synthesis of vinyl and L-ascorbyl phenolates and their inhibitory effects on advanced glycation end products
Hwang, Seung Hwan,Wang, Zhiqiang,Lim, Soon Sung
, p. 726 - 735 (2016/08/04)
This study successfully established the feasibility of a two-step chemo-enzymatic synthesis of L-ascorbyl phenolates. Intermediate vinyl phenolates were first chemically produced and then underwent trans-esterification with L-ascorbic acid in the presence of Novozyme 435 (Candida Antarctica lipase B) as a catalyst. Twenty vinyl phenolates and 11 ascorbyl phenolates were subjected to in vitro bioassays to investigate their inhibitory activity against advanced glycation end products (AGEs). Among them, vinyl 4-hydroxycinnamate (17VP), vinyl 4-hydroxy-3-methoxycinnamate (18VP), vinyl 4-hydroxy-3,5-dimethoxycinnamate (20VP), ascorbyl 4-hydroxy-3-methoxycinnamate (18AP) and ascorbyl 3,4-dimethoxycinnamate (19AP) showed 2–10 times stronger inhibitory activities than positive control (aminoguanidine and its precursors). These results indicated that chemo-enzymatically synthesized compounds have AGE inhibitory effect and thus are effective in either preventing or retarding glycation protein formation.