24974-75-2 Usage
General Description
2-Nitro-α-toluenesulfonyl chloride is a sulfonyl halide. It is reported to participate in the preparation of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents.
Check Digit Verification of cas no
The CAS Registry Mumber 24974-75-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,9,7 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 24974-75:
(7*2)+(6*4)+(5*9)+(4*7)+(3*4)+(2*7)+(1*5)=142
142 % 10 = 2
So 24974-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO4S/c8-14(12,13)5-6-3-1-2-4-7(6)9(10)11/h1-4H,5H2
24974-75-2Relevant articles and documents
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγInverse Agonist for Treatment of Castration-Resistant Prostate Cancer
Zhang, Yan,Wu, Xishan,Xue, Xiaoqian,Li, Chenchang,Wang, Junjian,Wang, Rui,Zhang, Cheng,Wang, Chao,Shi, Yudan,Zou, Lingjiao,Li, Qiu,Huang, Zenghong,Hao, Xiaojuan,Loomes, Kerry,Wu, Donghai,Chen, Hong-Wu,Xu, Jinxin,Xu, Yong
, p. 4716 - 4730 (2019/05/08)
We report the design, optimization, and biological evaluation of nuclear receptor RORγinverse agonists as therapeutic agents for prostate cancer treatment. The most potent compound 27 (designated as XY101) exhibited cellular activity with an IC50/su
