249741-91-1Relevant academic research and scientific papers
Apoptosis-inducing compounds
-
, (2008/06/13)
The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents.
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: Further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity
Campiani, Giuseppe,Morelli, Elena,Fabbrini, Monica,Nacci, Vito,Greco, Giovanni,Novellino, Ettore,Ramunno, Anna,Maga, Giovanni,Spadari, Silvio,Caliendo, Giuseppe,Bergamini, Alberto,Faggioli, Emanuela,Uccella, Ilaria,Bolacchi, Francesca,Marini, Stefano,Coletta, Massimiliano,Nacca, Angelo,Caccia, Silvio
, p. 4462 - 4470 (2007/10/03)
Pyrrolobenzoxazepinone (PBO) derivatives represent a new class of human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase (RT) inhibitors (NNRTs) whose prototype is (±)-6-ethyl-6-phenylpyrrolo[2,1- d][1,5]benzoxazepin-7(6H)-one (6
