249743-96-2Relevant academic research and scientific papers
Enantioselective preparation of 4-substituted cyclohexenes by radical fragmentation of sulfoxides
Imboden, Christoph,Villar, Felix,Renaud, Philippe
, p. 873 - 875 (2008/02/09)
(equation presented) Radical fragmentation of o-bromophenyl sulfoxides is reported. Starting from enantiomerically pure material, 4-substituted cyclohexene derivatives have been prepared with enantiomeric excesses between 70% and 86%. The key step of the process is a diastereoselective abstraction of a hydrogen atom by the initial aryl radical. The highest enantiomeric exesses have been obtained in the presence of aluminum Lewis acids.
