249757-20-8

Upstream product

• 193073-53-9 [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester 
• 191542-08-2 methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate 
• 193073-75-5 N-(tert-butoxycarbonyl)-(R)-(3,5-dichloro-4-methoxy)phenylglycine 
• 193073-48-2 (S)-N-(tert-butoxycarbonyl)-N-methyl-(S)-(4-fluoro-3-nitro)phenylalanine methyl ester 
• 193073-45-9 methyl 2-((tert-butoxycarbonyl)amino)-3-(4-fluoro-3-nitrophenyl)propanoate 
• 193073-38-0 (S)-N-(tert-butoxycarbonyl)-N-methyl-(S)-(4-fluoro-3-nitro)phenylalanine 
• 178744-39-3 L-4-fluoro-3-nitrophenylalanine methyl ester 
• 193073-85-7 methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(4-methoxyphenyl)acetate 
• 15017-52-4 4-(bromomethyl)-1-fluoro-2-nitrobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 20274-69-5 (4-fluoro-3-nitrophenyl)methanol 

Downstream Products

• 249757-14-0 [2-({(R)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(S)-(4-methoxyphenyl)acetic acid methyl ester 

Relevant academic research and scientific papers

Synthetic studies towards the synthesis of western and eastern chloropeptin I, II subunits

The western subunit (16-membered ring) was synthesized by the intramolecular SNAr reaction while the first 16-membered ring compound was obtained as a model of the eastern subunit via an intramolecular Ni0 mediated coupling reaction.