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249757-27-5

6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)purine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)purine

    Cas No: 249757-27-5

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  • 249757-27-5 Structure

  • Basic information

    1. Product Name: 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)purine
    2. Synonyms: 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)purine
    3. CAS NO:249757-27-5
    4. Molecular Formula:
    5. Molecular Weight: 569.06
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 249757-27-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)purine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)purine(249757-27-5)
    11. EPA Substance Registry System: 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)purine(249757-27-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 249757-27-5(Hazardous Substances Data)

249757-27-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 249757-27-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,9,7,5 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 249757-27:
(8*2)+(7*4)+(6*9)+(5*7)+(4*5)+(3*7)+(2*2)+(1*7)=185
185 % 10 = 5
So 249757-27-5 is a valid CAS Registry Number.

249757-27-5Relevant articles and documents

First evident generation of purin-2-yllithium: Lithiation of an 8-silyl- protected 6-chloropurine riboside as a key step for the synthesis of 2- carbon-substituted adenosines

Kumamoto, Hiroki,Tanaka, Hiromichi,Tsukioka, Ryota,Ishida, Yumiko,Nakamura, Akiko,Kimura, Satoe,Hayakawa, Hiroyuki,Kato, Keisuke,Miyasaka, Tadashi

, p. 7773 - 7780 (1999)

Lithiation at the 2-position of purine ring has been accomplished for the first time by using 6-chloro-9-(2,3-O-isopropylidene-5-O-trityl-β-D- ribofuranosyl)-8-(triisopropylsilyl)purine (7) as a substrate and LTMP as a lithiating agent. The 8-triisopropylsilyl group in 7 did not undergo anionic migration and, thus, allowed the ready generation of the C2-lithiated species by preventing deprotonation at the 8-position. The electron-withdrawing 6- chlorine atom plays an essential role to this C2-lithiation. Reactions of the lithiated species with electrophiles gave the 2-substituted products (Me, Et, i-Pr, CH(OH)C6H11, C(OH)Me2, CHO, CO2Me, and I) mostly in good yields. Ammonolysis of the 6-chlorine atom of these products (heating at 110 °C in a sealed tube with NH3/MeOH) effected simultaneous desilylation at the 8- position to give the corresponding adenosine analogues. The whole sequence provides a new and highly general method for the synthesis of 2-substituted adenosines.

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