249760-84-7Relevant academic research and scientific papers
Facile synthesis of a glycopeptide building block of antifreeze glycoprotein
Jiaang, Weir-Torn,Hsiao, Kwo-Feng,Chen, Shui-Tein,Wang, Kung-Tsung
, p. 1687 - 1690 (1999)
A new procedure for synthesizing a building block of antifreeze glycoprotein (AFGP) 1, Moz-Ala-(Galβ1 → 3GalNAααl)Thr-Ala-OH 7 has been developed. The onium salt is an important intermediate to generate α- glycopeptide 5 of excellent yield with high selectivity as a key step. One can successfully remove the Moz protective group of glycopeptide selectively with formic acid without cleaving the glycosidic bond.
