249764-06-5

Upstream product

• 249764-04-3 {2-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-hydroxymethyl-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 

Downstream Products

• 253329-83-8 {(S)-2-[5-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-phenyl]-1-[(1R,3S)-3-((R)-cyano-morpholin-4-yl-methyl)-8-hydroxy-5,7-dimethoxy-2,6-dimethyl-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 253329-78-1 (R)-{(1R,3S)-1-[(S)-1-Amino-2-(5-hydroxy-2,4-dimethoxy-3-methyl-phenyl)-ethyl]-8-hydroxy-5,7-dimethoxy-2,6-dimethyl-1,2,3,4-tetrahydro-isoquinolin-3-yl}-morpholin-4-yl-acetonitrile 
• 66082-27-7 Saframycin A 
• 429687-52-5 {1-[5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethoxy-3-methyl-benzyl]-2-cyano-2-[2-(4-hydroxy-butyl)-morpholin-4-yl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant academic research and scientific papers

NOVEL SAFRAMYCIN ANALOGS AS THERAPEUTIC AGENTS

The present invention is directed to saframcyin analogs that are useful in the treatment of cancer. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

NOVEL SAFRAMYCIN ANALOGS AS THERAPEUTIC AGENTS

The present invention is directed to saframcyin analogs that are useful in the treatment of cancer. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

Synthesis of highly epimerizable N-protected α-amino aldehydes of high enantiomeric excess

The Dess-Martin periodinane was found to be a superior oxidant for the efficient, epimerization-free synthesis of optically active N-protected α- amino aldehydes from the corresponding N-protected β-amino alcohols. Highly racemization-prone products, including N-Fmoc phenylglycinal and N- trifluoroacetyl α-amino aldehydes, were prepared in ≥95% yield with ≤ 1% epimerization. (C) 2000 Elsevier Science Ltd.