24978-24-3

Basic information

• Product Name: 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-1H-pyrrole-2,5-dione
• Synonyms: 3-(4-methoxyanilino)-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
• CAS NO: 24978-24-3
• Molecular Formula: C₁₈H₁₆N₂O₄
• Molecular Weight: 324.3306
• Mol File: 24978-24-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 505.3°C at 760 mmHg
• Flash Point: 259.4°C
• Density: 1.344g/cm³
• Vapor Pressure: 2.46E-10mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-1H-pyrrole-2,5-dione(24978-24-3)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-1H-pyrrole-2,5-dione(24978-24-3)

Safety Data

• Hazardous Substances Data: 24978-24-3(Hazardous Substances Data)

Usage

General Description

1-(4-methoxyphenyl)-3-[(4-methoxyphenyl)amino]-1H-pyrrole-2,5-dione, also known as sorafenib, is a chemical compound with potential medical applications. It is a kinase inhibitor that has been approved for the treatment of advanced renal cell carcinoma and hepatocellular carcinoma. Sorafenib works by inhibiting the activity of multiple protein kinases involved in tumor cell proliferation and angiogenesis, which can help to slow the growth and spread of cancer cells. Additionally, it has also shown promising results in the treatment of other types of cancer, including thyroid and breast cancer. However, sorafenib can also have potential side effects, such as hypertension, hand-foot skin reaction, and diarrhea, and it is important for patients to be monitored closely while taking this medication.

Upstream product

• 104-94-9 4-methoxy-aniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 98807-33-1 4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 

Relevant articles and documents

Aggregation induced emission characteristics of maleimide derivatives

A simple microwave assisted protocol for the construction of maleimides from various anilines and dialkyl acetylene dicarboxylates has been demonstrated. The AIE property of one of the maleimide derivatives has been studied in detail. The maleimide is AIE-active, and its color, fluorescence efficiency, quantum yield and fluorescence lifetime can be readily tuned by adding water to the THF solution. Compound 3a is found to be weakly luminescent when it is dissolved in THF, but its luminescence intensity increases enormously by the gradual addition of water up to 90% with associated increase in quantum yield and fluorescence lifetime. The Royal Society of Chemistry 2013.