249929-64-4Relevant academic research and scientific papers
Concise Xanthine Synthesis through a Double-Amidination Reaction of a 6-Chlorouracil with Amidines using Base-Metal Catalysis
Morel, Bénédicte,Franck, Philippe,Bidange, Johan,Sergeyev, Sergey,Smith, Dan A.,Moseley, Jonathan D.,Maes, Bert U. W.
, p. 624 - 628 (2017)
A new and concise route towards xanthines through a double-amidination reaction is described; consecutive intermolecular C?Cl and intramolecular oxidative C?H amidination. N-uracil amidines are obtained through SNAE on a 6-chlorouracil with amidines. Direct Cu-catalyzed oxidative C?H amidination on these N-uracil amidines yields polysubstituted xanthines. Sustainable oxidants, tBu2O2or O2, can be used in this oxidase-type reaction. The protocol allows for the introduction of N1, N3, N7, and C8 substituents during the xanthine-scaffold construction, thus avoiding post-functionalization steps. Both 6-chlorouracils and amidines are readily available commercially or through synthesis.
Double C-H activation: The palladium-catalyzed direct C-arylation of xanthines with arenes
Malakar, Chandi C.,Schmidt, Dietmar,Conrad, Juergen,Beifuss, Uwe
supporting information; experimental part, p. 1378 - 1381 (2011/05/03)
The novel Pd-catalyzed C(sp2)-H/C(sp2)-H cross-coupling of unactivated xanthines with unactivated arenes utilizing a combination of Ag(I) and O2 as oxidants exclusively yields C-8 arylated xanthines in a single synthetic o
Immunosuppressive effects of 8-substituted xanthine derivatives
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Page/Page column 2, (2008/06/13)
The invention relates to a novel use of 8-substituted xanthine derivatives for the manufacture of a medicament for the treatment of auto-immuno disorders.
