25012-75-3Relevant academic research and scientific papers
Synthesis and characterization of sulfide, sulfoxide and sulfone derivatives of thiopyran: antimicrobial evaluation
Pasha, Ghasem Firouzzade,Asghari, Sakineh,Tajbakhsh, Mahmoud,Mohseni, Mojtaba
, p. 7291 - 7306 (2017/10/06)
Abstract: A series of thiopyran derivatives and their oxidized analogous forms were synthesized and characterized by FT-IR, 1H, 13C, 31P NMR and mass spectroscopy techniques. The antibacterial and antifungal activities of these synthesized materials were evaluated against Staphylococcus aureus and Bacillus subtilis, as Gram-positive bacteria, and Escherichia coli and Pseudomonas aeruginosa, as Gram-negative bacteria, as well as the fungus Candida albicans. The results revealed that thiopyran S,S-dioxides are the most effective against all the bacteria studied in this work. Furthermore, thiopyran S-oxides showed excellent antifungal activity against Candida albicans.
Pummerer Rearrangements Using Chlorotrimethylsilane
Lane, Simon,Quick, Stephen J.,Taylor, Richard J. K.
, p. 2549 - 2552 (2007/10/02)
Attempted Pummerer rearrangement of 3-methoxycarbonylthian-4-one S-oxide in refluxing acetic anhydride gives unexpected products in which β-carbon oxidation and ring contraction has taken place.Treatment of 3-methoxycarbonylthian-4-one with N-chlorosuccinimide gives similar rearrngement products.These rearrangements are rationalised by the intermediacy of a common thiiranium ion.Chlorotrimethylsilane in refluxing tetrachloromethane efficiently effects the expected Pummerer rearrangement of 3-methoxycarbonylthian-4-one S-oxide into the corresponding α,β-unsaturated sulphides.Reactions of this reagent with related sulphoxides are also described.
