250139-17-4

Upstream product

• 250139-14-1 Acetic acid 5-((R)-3-acetoxy-1-isopropylsulfanyl-3,7-dimethyl-oct-6-enyl)-4-hydroxy-2,3-dimethyl-phenyl ester 
• 116119-14-3 Acetic acid (R)-1-(2-isopropylsulfanyl-ethyl)-1,5-dimethyl-hex-4-enyl ester 
• 116119-13-2 (R)-1-Isopropylsulfanyl-3,7-dimethyl-oct-6-en-3-ol 
• 116119-12-1 Toluene-4-sulfonic acid (R)-3-hydroxy-3,7-dimethyl-oct-6-enyl ester 
• 76936-25-9 (-)-(R)-3,7-Dimethyloct-6-en-1,3-diol 
• 50727-94-1 (2R,3R)-3-methyl-3-(4-methyl-3-pentenyl)oxiranemethanol 
• 106-24-1 Geraniol 

Relevant academic research and scientific papers

First enantioselective total synthesis of the endogenous natriuretic agent LLU-α

The endogenous natriuretic agent LLU-α, 1, has been synthesized from geraniol 4 in 13 steps and 18% overall yield. The two key steps are a Gassman-Sato process to give the phenol 8 and cyclization of the triol 10 with acid to give the chroman 12 with retention of configuration at the tertiary alcohol center. Final oxidation gave 1.