25017-30-5 Usage
Chemical class
Urea derivatives
Composition
Urea group (central carbonyl group attached to two amine groups) and a 4-methylphenyl group attached to an ethyl group
Usage
Organic synthesis and medicinal chemistry as a building block for various biologically active molecules
Potential pharmacological properties
Antiproliferative and antidiabetic activities
Applications
Pharmaceutical and chemical industries
Check Digit Verification of cas no
The CAS Registry Mumber 25017-30-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,0,1 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25017-30:
(7*2)+(6*5)+(5*0)+(4*1)+(3*7)+(2*3)+(1*0)=75
75 % 10 = 5
So 25017-30-5 is a valid CAS Registry Number.
25017-30-5Relevant articles and documents
Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5- trioxoimidazolidine-1-acetic acids
Ishii,Kotani,Nagaki,Shibayama,Toyomaki,Okukado,Ienaga,Okamoto
, p. 1924 - 1927 (2007/10/03)
A series of 3-(arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids (1) was prepared and tested for aldose reductase (AR) and aldehyde reductase (ALR) inhibitory activities. These compounds showed strong inhibitory activity against AR without significant inhibitory activity for ALR. The ratio of IC50(ALR)IC50(AR) was > 1000 in some compounds. On the basis of pharmacological tests such as the recovery of reduced motor nerve conduction velocity and toxicological profile, 3-(3-nitrobenzyl)-2,4,5- trioxoimidazolidine-1-acetic acid (NZ-314) was selected as the candidate for clinical development.