250248-85-2

Basic information

• Product Name: ((4S,5R)-2,2,6-Trioxo-4-phenyl-1,3-dioxa-2λ⁶-thia-7-aza-spiro[4.5]dec-7-yl)-acetic acid ethyl ester
• CAS NO: 250248-85-2
• Molecular Weight: 369.395
• Mol File: 250248-85-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((4S,5R)-2,2,6-Trioxo-4-phenyl-1,3-dioxa-2λ⁶-thia-7-aza-spiro[4.5]dec-7-yl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((4S,5R)-2,2,6-Trioxo-4-phenyl-1,3-dioxa-2λ⁶-thia-7-aza-spiro[4.5]dec-7-yl)-acetic acid ethyl ester(250248-85-2)
• EPA Substance Registry System: ((4S,5R)-2,2,6-Trioxo-4-phenyl-1,3-dioxa-2λ⁶-thia-7-aza-spiro[4.5]dec-7-yl)-acetic acid ethyl ester(250248-85-2)

Safety Data

• Hazardous Substances Data: 250248-85-2(Hazardous Substances Data)

Upstream product

• 250248-77-2 [(R)-3-Hydroxy-3-((S)-hydroxy-phenyl-methyl)-2-oxo-piperidin-1-yl]-acetic acid ethyl ester 
• 250248-71-6 {2-Oxo-3-[1-phenyl-meth-(E)-ylidene]-piperidin-1-yl}-acetic acid ethyl ester 
• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 53031-80-4 (E)-3-phenylmethylene-2-piperidinone 
• 3326-13-4 N-acetyl-2-piperidone 
• 675-20-7 piperidin-2-one 

Downstream Products

• 250249-00-4 ((R)-3-Benzyl-3-hydroxy-2-oxo-piperidin-1-yl)-acetic acid ethyl ester 

Relevant articles and documents

Asymmetric synthesis of novel quaternary α-hydroxy-δ-lactam dipeptide surrogates

Application of the Sharpless AD protocol to a series of α-(E)-benzylidene-δ-lactam precursors followed by selective deoxygenation provided efficient synthetic routes to the chiral quaternary α-hydroxy-γ-lactam derivatives 4 and 5. These functionalized intermediates and the diol precursors 3 are regarded as novel types of D-Phe-Pro dipeptide surrogates that are useful as enzyme active site probes.