250262-06-7Relevant academic research and scientific papers
Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells
Tagmose, Tina M.,Mogensen, John P.,Agerholm, Pia C.,Arkhammar, Per O.G.,Wahl, Philip,Worsaae, Anne,Hansen
, p. 1749 - 1752 (2001)
3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from pancreatic beta cells in vitro.
Arylcyanoguanidines as activators of Kir6.2/SUR1KATP channels and inhibitors of insulin release
Tagmose, Tina M.,Schou, S?ren C.,Mogensen, John P.,Nielsen, Flemming E.,Arkhammar, Per O. G.,Wahl, Philip,Hansen, Birgit S.,Worsaae, Anne,Boonen, Harrie C. M.,Antoine, Marie-Hélène,Lebrun, Philippe,Hansen, John Bondo
, p. 3202 - 3211 (2007/10/03)
Phenylcyanoguanidines substituted with lipophilic electron-withdrawing functional groups, e.g. N-cyano-N′ -[3,5-bis-(trifluoromethyl)phenyl]-N″-(cyclopentyl)guanidine (10) and N-cyano-N′-(3,5-dichlorophenyl)-N′-(3-methylbutyl)guanidine (12) were synthesiz
Substituted guanidines and diaminonitroethenes, their preparation and use
-
, (2008/06/13)
Guanidine and diaminonitroethene derivatives represented by the formula wherein X, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds are described. The se compounds are useful in the treatment o
