250263-80-0

Upstream product

• 250263-84-4 (2R,4R)-1-allyloxycarbonyl-4-tert-butyldimethylsilyloxy-2-[2-[4-[(E)-2-carbamoylethenyl]imidazol-1-yl]ethyl]pyrrolidine 
• 156442-53-4 (2R,4R)-1-allyloxycarbonyl-4-tert-butyldimethylsilyloxy-2-[2-(4-formylimidazol-1-yl)ethyl]pyrrolidine 
• 250263-72-0 (2R,4R)-1-allyloxycarbonyl-2-[2-[4-[(E)-2-carbamoylethenyl]imidazol-1-yl]ethyl]-4-hydroxypyrrolidine 
• 156441-21-3 (2R,4R)-1-allyloxycarbonyl-4-tert-butyldimethylsilyloxy-2-(2-methanesulfonyloxyethyl)pyrrolidine 
• 156441-20-2 (2R,4R)-1-allyloxycarbonyl-4-tert-butyldimethylsilyloxy-2-(2-hydroxyethyl)pyrrolidine 
• 156441-19-9 (2R,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-(2-hydroxyethyl)pyrrolidine 
• 156441-18-8 (2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-vinylpyrrolidine 
• 156440-98-1 (2S,4R)-N-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbaldehyde 
• 154343-02-9 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzyl-2-hydroxy-methyl-pyrrolidin 
• 98-91-9 thiobenzoic acid 
• 250263-85-5 (2R,4R)-1-allyloxycarbonyl-2-[2-[4-[(E)-2-carbamoylethenyl]imidazol-1-yl]ethyl]-4-(methanesulfonyloxy)pyrrolidine 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapanems. Part III: Novel 2-alkyl substituents containing cationic heteroaromatics linked via a C-N bond

The synthesis and biological activity of a novel series of 2-alkyl-4-pyrrolidinylthio-β-methylcarbapenems containing a variety of cationic heteroaromatic substituents is described. As a result of these studies, we uncovered a relationship between in vitro antibacterial activity and the length of the alkyl spacer part, and discovered FR20950 (1c), containing a two methylene spacer moiety and an imidazolio group, which possesses a balanced spectrum of antibacterial activity, including Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA). Furthermore, FR20950 exhibited excellent urinary recovery, and com- parable stability against renal dehydropeptidase-I (DHP-I) to Biapenem. DHP-I stability could be improved by introduction of a substituent on to the imidazole ring. (C) 1999 Elsevier Science Ltd. All rights reserved.

Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents

A compound of the formula: STR1 in which R1 is carboxy or protected carboxy, R2 is 1-hydroxyethyl, R3 is methyl, R4 is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lo