250264-28-9

Basic information

• Product Name: 5-chloro-1,8-naphthyridin-2(1H)-one
• Synonyms: 5-chloro-1,8-naphthyridin-2(1H)-one
• CAS NO: 250264-28-9
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.59
• Mol File: 250264-28-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-chloro-1,8-naphthyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-1,8-naphthyridin-2(1H)-one(250264-28-9)
• EPA Substance Registry System: 5-chloro-1,8-naphthyridin-2(1H)-one(250264-28-9)

Safety Data

• Hazardous Substances Data: 250264-28-9(Hazardous Substances Data)

Upstream product

• 250264-27-8 2-amino-5?chloro-1,8-naphthyridine 
• 749925-47-1 tert-butyl-3-{4-chloro-2-[(2,2-dimethylpropanoyl)amino]pyridin-3-yl}-3-hydroxypropanoate 
• 33007-28-2 2-acetamido-5?chloro-1,8-naphthyridine 

Downstream Products

• 1203509-61-8 N-(4-(7-oxo-7,8-dihydro-1,8-naphthyridin-4-yl-amino)phenyl)benzamide 

Relevant articles and documents

Synthesis of 1,8-naphthyridine derivatives: Potential antihypertensive agents - Part VIII

A series of (ethoxycarbonylpiperazinyl)- and piperazinyl- 1,8- naphthyridine derivatives, variously substituted, has been synthesized and pharmacologically investigated for anthihypertensive activity. Some of them exhibited a significant and prolonged decrease of the mean arterial pressure (MAP) on spontaneously hypertensive rats. On the basis of the pharmacological results, no structure-activity relationship can be deduced at this time. Moreover, the most active compound 4e, was investigated by means of in vitro pharmacological functional studies and in vivo, as a diuretic agent, to determine a possible mechanism of the antihypertensive activity, which results in a probably non-competitive antagonism against α1 vascular adrenoceptors. This mechanism was also shown by the compounds 8 and 13.